Related Experiment Video
Updated: Sep 7, 2025
12:18
A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
Published on: January 11, 2020
7.6K
Cardiometabolic multimorbidity accelerates cognitive decline and dementia progression
Abigail Dove1, Anna Marseglia2, Ying Shang3
1Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
Summary
Multiple cardiometabolic diseases (CMDs) significantly accelerate cognitive decline and increase the risk of cognitive impairment, no dementia (CIND), and dementia in older adults.
Area of Science:
- Neurology
- Gerontology
- Cardiology
Background:
- Cardiometabolic diseases (CMDs) are individually linked to cognitive decline.
- The combined impact of multiple CMDs on cognitive health remains under-investigated.
Purpose of the Study:
- To investigate the cumulative effect of cardiometabolic diseases on cognitive function in older adults.
- To determine if cardiometabolic multimorbidity accelerates cognitive decline and the onset of dementia.
Main Methods:
- Longitudinal study of 2577 dementia-free adults aged 60+ over 12 years.
- Assessed cardiometabolic diseases (type 2 diabetes, heart disease, stroke) and cardiometabolic multimorbidity (≥2 CMDs) at baseline.
- Utilized linear mixed-effects models, Cox regression, and Laplace regression to analyze cognitive changes and incident cognitive impairment, no dementia (CIND) and dementia.
Main Results:
- Cardiometabolic multimorbidity was significantly associated with accelerated cognitive decline.
- Increased risk of CIND (HR 1.73) and dementia (HR 1.86) observed with CMD multimorbidity.
- CMD multimorbidity advanced the onset of CIND by 2.3 years and dementia by 1.8 years.
Conclusions:
- Cardiometabolic multimorbidity accelerates cognitive decline and elevates the risk of cognitive impairment and dementia.
- Targeting co-morbid CMDs may be crucial for interventions aimed at preserving cognitive health in aging populations.
Related Concept Videos
01:30Coronary Artery Disease I: Introduction
54
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
54
01:30Dementia
165
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
The progression of dementia is generally gradual....
165
01:30Cardiomyopathy II: Dilated Cardiomyopathy
21
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
21
01:27Psychoneuroimmunology: Cardiovascular Disease
75
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
75
01:26Alzheimer's Disease: Overview
664
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
664
01:29Cardiomyopathy III: Hypertrophic Cardiomyopathy
45
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
45