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New concepts in regulation and function of the FGF23
Sanaz Dastghaib1, Farhad Koohpeyma1, Mesbah Shams1
1Endocrinology and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, P.O. Box 71345-1744, Iran.
Clinical and Experimental Medicine
|June 16, 2022
Summary
Phosphate homeostasis is poorly understood compared to calcium regulation. Fibroblast growth factor 23 (FGF23) is a key regulator, but its precise functions and interactions with other minerals require further research for therapeutic applications.
Area of Science:
- Endocrinology
- Mineral Metabolism
- Bone Biology
Background:
- Phosphate homeostasis is less understood than calcium regulation.
- The parathyroid hormone (PTH)/vitamin D axis is the traditional framework for mineral metabolism.
- Fibroblast growth factor 23 (FGF23), produced by osteocytes, is a key regulator of phosphate homeostasis.
Purpose of the Study:
- To provide an overview of novel findings in FGF23 regulation and function.
- To highlight unanswered questions and hypotheses regarding FGF23.
- To discuss the role of FGF23 in mineral homeostasis based on recent research.
Main Methods:
- Literature review of FGF23 research.
- Analysis of the hormonal bone-parathyroid-kidney axis.
- Focus on recent experimental findings regarding FGF23.
Main Results:
- FGF23 secretion is influenced by diet, serum phosphate, PTH, and vitamin D.
- FGF23, its receptors, and α-Klotho mediate FGF23 actions.
- The intricate crosstalk among FGF23, phosphate, calcium, PTH, and vitamin D is not fully elucidated.
Conclusions:
- Further research is needed to clarify FGF23's regulation and functions.
- Understanding FGF23's role is crucial for potential therapeutic applications.
- Recent findings offer insights but leave many questions about mineral homeostasis unanswered.
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