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Another win for mimetic peptides in stroke: Disruption of TRPM2-NMDAR signaling
Andrew K J Boyce1, Roger J Thompson1
1Department of Cell Biology and Anatomy, Hotchkiss Brain Institute, University of Calgary, Calgary, AB T2N4N1, Canada.
Neuron
|June 16, 2022
Abstract:
Glutamate excitotoxicity during ischemia triggers an intracellular signaling avalanche leading to cell death, yet blocking NMDA receptors directly in human stroke trials failed. In this issue of Neuron, Zong et al. (2022) disrupt downstream NMDAR-TRPM2 coupling to improve stroke outcomes, supporting intracellular NMDAR signaling as an alternate therapeutic target.
