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Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports
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Therapeutic Targeting of Macrophage Plasticity Remodels the Tumor-Immune Microenvironment
Hee-Jin Jang1, Hyun-Sung Lee1, Wendong Yu2
1Systems Onco-Immunology Laboratory, The David J. Sugarbaker Division of Thoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas.
Cancer Research
|June 16, 2022
Abstract
Significance:
Comprehensive single-cell proteomics analyses of lung adenocarcinoma progression reveal the role of tumor-associated macrophages in resistance to PD-1 blockade therapy. See related commentary by Lee et al., p. 2515.
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