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Benefits of plasma exchange on mortality in patients with COVID-19: a systematic review and meta-analysis

Jinlv Qin1, Guizuo Wang2, Dong Han2

  • 1Radioimmunoassay Center, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi 710068, China.

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
|June 16, 2022
PubMed

Insights

Therapeutic plasma exchange (TPE) significantly reduced mortality in COVID-19 patients. This treatment should be considered for hospitalized individuals with moderate-to-critical illness to improve survival rates.

Area of Science:

  • Infectious Diseases
  • Critical Care Medicine
  • Hematology

Background:

  • The COVID-19 pandemic has caused a significant global mortality increase.
  • Therapeutic plasma exchange (TPE) is a potential treatment modality for severe infections.

Purpose of the Study:

  • To evaluate the efficacy of TPE in reducing mortality among COVID-19 patients.
  • To conduct a systematic review and meta-analysis of controlled clinical trials comparing TPE with standard care for COVID-19.

Main Methods:

  • Systematic literature search of PubMed, Embase, Cochrane Library, and clinicaltrials.gov.
  • Inclusion of controlled clinical trials comparing TPE with standard of care for COVID-19.
  • Meta-analysis using risk ratios (RRs) and weighted mean differences with 95% confidence intervals (CIs).

Main Results:

  • Six trials with 343 participants met the inclusion criteria.
  • Therapeutic plasma exchange demonstrated a significant reduction in mortality (RR 0.41, 95% CI 0.24 to 0.69; P = 0.0008).

Conclusions:

  • TPE significantly decreases mortality in hospitalized patients with moderate-to-critical COVID-19.
  • Plasma exchange therapy is a viable consideration for managing COVID-19 patients.
  • Further research may explore TPE's role in different stages of COVID-19 severity.
Abstract

Keywords:
COVID-19Meta-analysisMortalityPlasma exchange

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