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Fully Guided Tooth Bud Ablation in Pigs Results in Complete Tooth Bud Removal and Molar Agenesis.

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Fully Guided Third Molar Tooth Bud Ablation in Pigs.

Leigh E Colby1

  • 1Private Practitioner and President & CEO of TriAgenics, Inc, TriAgenics, Inc, Redmond, OR.

Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons
|June 16, 2022
PubMed
Summary

This study shows that microwave energy can successfully ablate third molar (3M) tooth buds in pigs, offering a less invasive alternative to surgical removal. The developed protocol demonstrates potential for future research into inducing molar agenesis.

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Area of Science:

  • Biomedical Engineering
  • Oral Surgery
  • Animal Models

Background:

  • Third molar (3M) removal is a common surgical procedure.
  • Current surgical techniques can be invasive.
  • A less invasive alternative for 3M management is needed.

Purpose of the Study:

  • To selectively ablate third molar (3M) tooth buds in a pig model.
  • To demonstrate a less-invasive alternative to surgical 3M removal.
  • To evaluate a novel 3M ablation (3TBA) protocol.

Main Methods:

  • A mandibular split-mouth pig model was developed, utilizing pigs due to the dimensional similarity of their 3M tooth buds to humans.
  • Microwave energy thermal doses were delivered to thermocoagulate 3M tooth bud tissues within bony crypts.
  • Computed tomography scans informed predetermined microwave thermal doses, followed by mandibular dissection for comparison.

Main Results:

  • All 5 pigs successfully underwent the fully guided 3M tooth bud ablation (3TBA) procedure.
  • Complete thermocoagulation of the targeted 3M tooth bud volume was achieved in all cases.
  • No visual damage to structures outside the bony crypt was observed.

Conclusions:

  • The developed animal model and 3TBA protocol are suitable for demonstrating a fully guided ablation.
  • This approach shows promise as a less-invasive method for 3M management.
  • The study supports the use of this model for future long-term studies on inducing molar agenesis.