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Stem Cell Niche

Stem Cell Niche

The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...

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The neural stem cell secretome across neurodevelopment.

Tyler J Dause¹, Jiyeon K Denninger¹, Bryon M Smith¹

¹Department of Psychology, The Ohio State University, United States.

Experimental Neurology

|June 16, 2022

Summary

Neural stem cell (NSC) secretomes regulate their own function and environment throughout life. Further research is needed to understand their role in central nervous system (CNS) injury for better regenerative therapies.

Keywords:

Neural progenitor cell Neural stem cell Neurodevelopment Radial glia Secretome

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Enumeration of Neural Stem Cells Using Clonal Assays

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Published on: October 4, 2016

Area of Science:

Neuroscience
Regenerative Medicine
Cell Biology

Background:

Neural stem cells (NSCs) are key to central nervous system (CNS) repair.
The NSC secretome, a collection of secreted products, shows therapeutic potential.
Understanding the endogenous secretome informs NSC therapy development.

Purpose of the Study:

To review the autocrine and paracrine functions of the endogenous NSC secretome across life.
To highlight the role of the NSC secretome in self-regulation and niche interaction.
To identify research gaps, particularly in injured CNS contexts.

Main Methods:

Literature review focusing on endogenous NSC secretome functions.
Analysis of studies examining NSC secretome across developmental and adult stages.
Identification of research gaps in clinically relevant scenarios.

Main Results:

The NSC secretome plays a crucial role in regulating endogenous NSCs and their niche throughout development and adulthood.
Evidence supports both autocrine and paracrine functions of the NSC secretome.
Significant gaps exist in understanding paracrine functions in injured CNS environments.

Conclusions:

The endogenous NSC secretome is vital for NSC self-regulation and niche maintenance.
Further research into the paracrine functions of the NSC secretome in injured CNS is essential.
A deeper understanding will advance the development of safe and effective NSC-based therapies.