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Contemporary Management of Refractory Angina

Rebekah Lantz1, Odayme Quesada2, Georgia Mattingly1

  • 1The Lindner Research Center at the Christ Hospital, 2123 Auburn Avenue, Suite 424, Cincinnati, OH 45219, USA.

Interventional Cardiology Clinics
|June 16, 2022
PubMed

Insights

Refractory angina (RA) causes chest pain from coronary ischemia despite treatment. This review explores new invasive and noninvasive therapies for RA patients with limited options.

Area of Science:

  • Cardiology
  • Vascular Medicine
  • Interventional Cardiology

Background:

  • Refractory angina (RA) is persistent chest pain due to coronary ischemia.
  • Patients have advanced coronary artery disease (CAD) unresponsive to revascularization.
  • Optimal medical therapy improves prognosis but quality of life remains impaired.

Purpose of the Study:

  • To review novel invasive and noninvasive therapies for refractory angina.
  • To highlight emerging treatment options for patients with limited choices.

Main Methods:

  • Literature review of current and emerging RA treatments.
  • Analysis of invasive and noninvasive therapeutic strategies.
  • Synthesis of data on novel investigational therapies.

Main Results:

  • Maximal medical therapy and risk factor modification improve long-term prognosis.
  • Despite advances, RA patients face significant quality of life impairment.
  • Limited treatment options persist for refractory cases.

Conclusions:

  • Novel invasive and noninvasive therapies are under investigation for RA.
  • These emerging treatments offer potential hope for patients with refractory angina.
  • Further research is needed to establish efficacy and safety of new RA therapies.

Keywords:
AnginaCoronary artery diseaseMicrovascular

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