Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

70
Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
70
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

85
Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
85
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

57
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
57
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

70
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
70
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

44
Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
44
Acute Kidney Injury VI: Nursing Management01:22

Acute Kidney Injury VI: Nursing Management

55
Acute Kidney Injury (AKI) results in an inability to maintain fluid, electrolyte, and acid-base balance. Effective nursing management is critical in improving patient outcomes and includes comprehensive patient assessment and targeted interventions.Comprehensive Patient AssessmentA detailed history collection is essential, focusing on any recent infections, nephrotoxic medication use, or chronic conditions such as hypertension and diabetes that may contribute to AKI. During the physical...
55

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Creatinine muscle index in UK Biobank: comparison with MRI and associations with frailty and mortality.

Clinical kidney journal·2026
Same author

Feasibility of obtaining endothelial cells from major surgery and critically ill patients.

VASA. Zeitschrift fur Gefasskrankheiten·2026
Same author

Early biomarker detection: fundamentally disputable?

Intensive care medicine·2026
Same author

The nephrotoxic effects of anti-cancer therapies: consensus report of the 34th Acute Disease Quality Initiative workgroup.

Nature reviews. Nephrology·2025
Same author

Comparison of two different bicarbonate replacement fluids during CVVH with RCA: a prospective, randomized, controlled trial.

Intensive care medicine·2025
Same author

Factors influencing multidisciplinary clinical decision-making in the critical care unit: a systematic review and mixed-methods meta-synthesis.

BJA open·2025

Related Experiment Video

Updated: Sep 7, 2025

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
09:02

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion

Published on: February 2, 2021

4.6K

Postoperative Acute Kidney Injury.

Naomi Boyer1,2, Jack Eldridge3,4, John R Prowle3,4

  • 1Department of Critical Care, Royal Surrey Hospital, Guildford, United Kingdom.

Clinical Journal of the American Society of Nephrology : CJASN
|June 17, 2022
PubMed
Summary

Postoperative acute kidney injury (AKI) is common after major surgery. Novel biomarkers and perioperative interventions may improve diagnosis and outcomes for this serious complication.

Keywords:
Critical Care Nephrology and Acute Kidney Injury Seriesacute kidney injurybiomarkerskidney replacement therapyperioperativepostoperativesurgery

More Related Videos

Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research
03:13

Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research

Published on: November 3, 2023

2.4K
Bilateral Renal Ischemia-Reperfusion Model for Acute Kidney Injury in Mice
02:45

Bilateral Renal Ischemia-Reperfusion Model for Acute Kidney Injury in Mice

Published on: February 2, 2024

1.8K

Related Experiment Videos

Last Updated: Sep 7, 2025

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
09:02

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion

Published on: February 2, 2021

4.6K
Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research
03:13

Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research

Published on: November 3, 2023

2.4K
Bilateral Renal Ischemia-Reperfusion Model for Acute Kidney Injury in Mice
02:45

Bilateral Renal Ischemia-Reperfusion Model for Acute Kidney Injury in Mice

Published on: February 2, 2024

1.8K

Area of Science:

  • Nephrology
  • Critical Care Medicine
  • Surgical Complications

Background:

  • Postoperative acute kidney injury (AKI) is a frequent complication following major surgery.
  • AKI is linked to increased patient morbidity and mortality.
  • Current diagnostic criteria (Kidney Disease Improving Global Outcomes) using serum creatinine and urine output may lack accuracy in the postoperative setting.

Purpose of the Study:

  • To explore the limitations of conventional diagnostic criteria for postoperative AKI.
  • To highlight the potential of novel biomarkers for refining AKI diagnosis.
  • To identify modifiable risk factors for preventing postoperative AKI.

Main Methods:

  • Review of current literature on postoperative AKI diagnosis and management.
  • Analysis of conventional diagnostic criteria (serum creatinine, urine output).
  • Exploration of novel biomarker applications and risk factor identification (preoperative, intraoperative, postoperative).

Main Results:

  • Conventional AKI diagnostic criteria may be imprecise in the postoperative period.
  • Novel biomarkers show promise for improved AKI detection.
  • Risk factors for AKI can be categorized and targeted perioperatively.
  • Current treatment is mainly supportive, with potential benefits from management bundles.

Conclusions:

  • Refining AKI diagnosis with novel biomarkers is warranted.
  • Perioperative strategies targeting identified risk factors can mitigate AKI development.
  • Management bundles may enhance outcomes for patients with postoperative AKI.