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Serum folate levels and hypertension.
Yoonkyung Lee1, Sangshin Park2,3
1Graduate School of Urban Public Health, University of Seoul, 163 Seoulsiripdae-ro, Dongdaemun-gu, Seoul, 02504, Republic of Korea.
Scientific Reports
|June 17, 2022
Summary
This study found no significant link between higher serum folate levels and reduced hypertension risk in Korean adults. Folate levels did not impact blood pressure or the likelihood of developing hypertension.
Area of Science:
- Nutrition Science
- Cardiovascular Health
- Public Health
Background:
- Hypertension is a major global health concern.
- Folate plays a role in cardiovascular health.
- The relationship between folate levels and hypertension requires further investigation.
Purpose of the Study:
- To investigate the association between serum folate levels and hypertension in Korean adults.
- To analyze the impact of folate levels on blood pressure.
- To determine if higher folate levels correlate with lower hypertension risk.
Main Methods:
- Utilized data from the Korea National Health and Nutrition Examination Survey (2016-2018).
- Included 6343 Korean adults with measured blood pressure and serum folate levels.
- Employed multivariable logistic and linear regression models, analyzing folate levels across quintiles.
Main Results:
- The average serum folate level was 7.4 ng/mL, with a hypertension prevalence of 30.4%.
- No significant differences in systolic or diastolic blood pressure were observed across folate level quintiles.
- No statistically significant linear relationship was found between serum folate levels and blood pressure or hypertension odds.
Conclusions:
- High serum folate levels were not significantly associated with a lower risk of hypertension in Korean adults.
- Folate supplementation may not be a direct strategy for hypertension prevention in this population.
- Further research is needed to explore other factors influencing hypertension in relation to folate metabolism.
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