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Are H1 and H3 haplotypes of endothelial protein C receptor (PROCR) an important factor in contracting COVID-19?

Mehmet Reşat Ceylan1, Nazım Kankılıç2, Özlem Öz3

  • 1Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Campus of Osmanbey, University of Harran, Şanlıurfa, Turkey.

Journal of Medical Virology
|June 17, 2022
PubMed

Insights

Genetic factors influence COVID-19 susceptibility. Specific endothelial protein C receptor (PROCR) haplotypes, PROCR H1 and PROCR H3, were found to be associated with increased risk of contracting COVID-19 infection.

Area of Science:

  • Cardiovascular Genetics
  • Infectious Disease Epidemiology

Background:

  • COVID-19 (coronavirus 2019) infection can lead to cardiovascular disease and myocardial damage.
  • Understanding the interplay between genetic predispositions and COVID-19 infection is crucial for risk assessment.

Purpose of the Study:

  • To investigate the relationship between genetic cardiovascular risk factors and COVID-19 infection.
  • To identify specific genetic markers associated with COVID-19 susceptibility and severity.

Main Methods:

  • Study included 135 patients: 27 COVID-19 negative and 108 COVID-19 positive.
  • Patients were categorized into three groups: COVID-19 negative, asymptomatic COVID-19 positive, and symptomatic COVID-19 positive with pulmonary involvement.
  • New generation sequencing was used to analyze genetic cardiovascular risk factors in blood samples.

Main Results:

  • No significant differences in several genetic factors (fibrinogen, HPA1, ACE, AGT, AGTR1, Apo E, eNOS) were found across the groups.
  • Significant differences were observed in endothelial protein C receptor (PROCR) gene variants: PROCR H3 haplotype/G (A3 haplotype) and PROCR H1 haplotype/C (A1 haplotype).
  • COVID-19 positivity was more common in individuals with PROCR H1 haplotype/C and PROCR H3 haplotype/G genotypes.

Conclusions:

  • PROCR H1 and PROCR H3 haplotypes may play a significant role in susceptibility to COVID-19 infection.
  • Identifying PROCR genetic variations and measuring soluble EPCR (sEPCR) levels could aid in managing COVID-19 patients.

Keywords:
COVID-19PROCR H1PROCR H3sEPCR

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