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PET Imaging of Neuroinflammation Using [11C]DPA-713 in a Mouse Model of Ischemic Stroke
Published on: June 14, 2018
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D3 Receptors and PET Imaging.
Sheida Koohsari1, Yanghong Yang1, David Matuskey2,3,4
1Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA.
Current Topics in Behavioral Neurosciences
|June 17, 2022
Summary
Positron emission tomography (PET) imaging reveals dopamine D3 receptor (D3R) changes in conditions like addiction and Parkinson's disease. Research focuses on [11C]PHNO and developing new D3R radiotracers.
Area of Science:
- Neuroscience
- Radiochemistry
- Molecular Imaging
Background:
- The dopamine D3 receptor (D3R) plays a crucial role in various neurological and psychiatric conditions.
- Positron emission tomography (PET) is a powerful in vivo imaging technique for molecular-level investigations.
Purpose of the Study:
- To introduce PET imaging for detecting D3R changes.
- To review available D3R radiotracers, particularly [11C]PHNO.
- To discuss PET findings related to D3R in specific diseases and aging.
Main Methods:
- Utilizing PET imaging to visualize and quantify D3R availability in the brain.
- Reviewing and discussing the properties of various D3R radiotracers.
- Analyzing published PET data in diverse clinical populations.
Main Results:
- PET imaging allows for molecular-level detection of D3R alterations in vivo.
- [11C]PHNO is a key radiotracer for D3R imaging.
- Significant D3R changes are observed in substance abuse, obesity, TBI, schizophrenia, Parkinson's disease, and aging.
Conclusions:
- PET imaging of D3R provides valuable insights into brain function and disease mechanisms.
- Continued development of selective D3R radiotracers is essential for advancing research and clinical applications.
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