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Angiotensin Receptor Blockers Associated Enteropathy-Brief Report

Neha Gosai1, Falgun Gosai2

  • 1Avalon School of Medicine, Curaçao, USA.

Journal of Community Hospital Internal Medicine Perspectives
|June 17, 2022
PubMed

Insights

The association between Olmesartan, other angiotensin receptor blockers (ARBs), and Celiac sprue-like enteropathy (CSLE) remains unclear. Further research is needed to clarify this relationship, considering patient factors and medication duration.

Area of Science:

  • Gastroenterology
  • Pharmacology

Background:

  • Olmesartan and other angiotensin receptor blockers (ARBs) are commonly prescribed antihypertensive medications.
  • Celiac sprue-like enteropathy (CSLE) is a rare gastrointestinal disorder.
  • Previous studies have reported conflicting results on the association between ARB use and CSLE.

Purpose of the Study:

  • To systematically review and synthesize existing literature on the association between angiotensin receptor blockers (ARBs) and Celiac sprue-like enteropathy (CSLE).
  • To evaluate the current evidence regarding the potential link between ARB medications and the development of CSLE.

Main Methods:

  • Literature search of case reports, case series, and observational studies.
  • Analysis of studies investigating the association between Olmesartan/ARBs and CSLE.
  • Synthesis of findings to assess the strength of evidence for an association.

Main Results:

  • The current literature presents equivocal findings regarding the association between ARB use and CSLE.
  • Reported associations vary based on patient populations, geographical regions, and duration of ARB therapy.
  • Mixed results from case reports, case series, and observational studies highlight the complexity of this relationship.

Conclusions:

  • The relationship between angiotensin receptor blockers (ARBs) and Celiac sprue-like enteropathy (CSLE) is not definitively established.
  • Factors such as patient demographics, geographic location, and medication exposure duration may influence the observed association.
  • Further high-quality research is warranted to elucidate the potential link between ARBs and CSLE.

Keywords:
ARBDiarrheaOlmesartanSprue like enteropathy

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