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Visualization of Streptococcus pneumoniae within Cardiac Microlesions and Subsequent Cardiac Remodeling
Published on: April 7, 2015
Catastrophic Perforation in Streptococcus Pneumoniae Aortitis: Complications of Infective Endocarditis in the Current
Sana Shaikh1, Jorge I Peña Garcia2, Michelle Shieh3
1Division of Nephrology, Washington University School of Medicine, St. Louis, MO 63117, USA.
Abstract:
Infectious aortitis is an uncommon but life-threatening cause of aortitis. Given the lack of specific symptoms, establishing the diagnosis is often a challenge. When it is associated with an endovascular infection, such as infective endocarditis, blood cultures may be diagnostic although often limited by low positive predictive value. Imaging studies may reveal characteristic findings, with computerized tomography angiography being the most sensitive. Management includes prompt initiation of antimicrobial therapy followed by surgical intervention, keeping in mind that operative mortality is high due to weakened arterial wall integrity. Here we describe a 25-year-old woman without relevant medical history, who presented to the hospital with subacute onset of fever, back pain and malaise, and was found to have infectious aortitis secondary to Streptococcus pneumoniae endocarditis. Despite appropriate antimicrobial coverage and surgical repair attempts, she succumbed to aortic perforation after a complicated and prolonged hospitalization.
Insights
Infectious aortitis, often secondary to infective endocarditis, presents diagnostic challenges due to non-specific symptoms. This case highlights the critical need for prompt diagnosis and management of this life-threatening condition.
Area of Science:
- Cardiology
- Infectious Diseases
- Vascular Surgery
Background:
- Infectious aortitis is a rare but severe condition affecting the aorta.
- Diagnosis can be challenging due to vague symptoms and limitations of diagnostic tests.
Observation:
- A young woman presented with fever, back pain, and malaise, later diagnosed with infectious aortitis.
- The aortitis was secondary to Streptococcus pneumoniae infective endocarditis.
Findings:
- Computerized tomography angiography is a sensitive imaging modality for diagnosing infectious aortitis.
- Blood cultures can aid diagnosis but have a low positive predictive value.
Implications:
- Prompt antimicrobial therapy and surgical intervention are crucial for managing infectious aortitis.
- High operative mortality is associated with infectious aortitis due to compromised aortic wall integrity.
- This case underscores the aggressive nature of infectious aortitis, even with appropriate treatment.
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