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Updated: Jul 26, 2026

VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma
Published on: December 28, 2015
Intravascular Large B Cell Lymphoma - Still a Diagnostic Dilemma
Abuzar A Asif1, Manisha Tharoor1, Jacqueline L Fischer1
1Department of Internal Medicine, University of Illinois College of Medicine, Peoria, IL, USA.
Abstract:
Intravascular large B cell lymphoma (IVLBCL), a rare subtype of diffuse large B cell lymphoma (DLBCL), presents with non-specific symptoms and is an extremely difficult diagnosis to make despite extensive workup. It very rarely presents with endocrinologic abnormalities. We present a case of an 81-year-old woman whose predominant presenting manifestation was endocrinopathy, who passed away from multiorgan failure, and was diagnosed to have IVLBCL on post mortem autopsy.

