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Admission Levels of Serum P-Selectin and IL-6 Can Predict Development of Deep Venous Thrombosis in Hospitalized

Nehal Farouk1, Walaa Mohamed Omar Ashry2, Hanan A El-Hagrasy3

  • 1Vascular Surgery Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.

International Journal of General Medicine
|June 17, 2022
PubMed

Insights

Elevated levels of Interleukin-6 (IL-6) and P-selectin are linked to deep venous thrombosis (DVT) in hospitalized COVID-19 patients. These markers may play a role in DVT development during infection.

Area of Science:

  • Medical Research
  • Infectious Diseases
  • Hematology

Background:

  • Deep venous thrombosis (DVT) is a frequent complication in COVID-19 patients.
  • Elevated levels of Interleukin-6 (IL-6) and P-selectin have been observed in COVID-19.
  • The relationship between these markers and DVT in COVID-19 requires further investigation.

Purpose of the Study:

  • To evaluate P-selectin and IL-6 levels in COVID-19 patients with DVT.
  • To explore the association between these inflammatory markers and clinical/laboratory parameters in COVID-19 patients with DVT.

Main Methods:

  • Retrospective study of 150 hospitalized COVID-19 patients.
  • Measurement of IL-6 and P-selectin using enzyme-linked immunosorbent assay.
  • Diagnosis of DVT via Doppler ultrasound of the lower extremities.

Main Results:

  • DVT developed in 39.3% of patients.
  • Patients with DVT exhibited significantly higher P-selectin and IL-6 levels (p < 0.001).
  • P-selectin and IL-6 demonstrated good performance in identifying DVT (AUCs 0.72-0.86).
  • Severe disease, elevated P-selectin, and elevated IL-6 were significant predictors of DVT.

Conclusions:

  • Elevated P-selectin and IL-6 levels are likely involved in DVT development in hospitalized COVID-19 patients.
  • These markers may serve as potential indicators for DVT risk in this population.
Abstract

Keywords:
Covid-19deep venous thrombosisinterleukin 6

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