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Isolation, Processing and Analysis of Murine Gingival Cells
Published on: July 2, 2013
Refining the Mechanism of Drug-Influenced Gingival Enlargement and Its Management
Muhammad Annurdin Sabarudin1, Haslina Taib2, Wan Majdiah Wan Mohamad3
1Department of Periodontology and Community Oral Health, Faculty of Dentistry, Universiti Sains Islam Malaysia, Kuala Lumpur, MYS.
Abstract:
Drug-influenced gingival enlargement (DIGE) or overgrowth manifests as abnormal enlargement of the gingiva due to an adverse effect of certain drug reactions in patients treated with anticonvulsants, immunosuppressants, or calcium channel blockers (CCBs). As the gingival enlargement became significant, it may interfere with the normal oral hygiene measures, aesthetics, as well as masticatory functions of the patients. The exact mechanism of how this undesirable condition develops is yet unknown, and complicated, with non-inflammatory and inflammatory pathways involved. This review illuminates these putative pathways of DIGE and highlights various treatment approaches based on existing research and current observations.
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