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Updated: Sep 7, 2025

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation
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Published on: February 28, 2012

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Dronedarone for Atrial Fibrillation Prophylaxis in Patients Undergoing Open Heart Surgical Interventions: A Case

Jay D Patel1,2, Mrhaf Alsamman1,2, Dewansh Goel1,2

  • 1GME Internal Medicine Residency, University of Central Florida College of Medicine-Ocala Campus, Ocala, FL, USA.

Journal of Community Hospital Internal Medicine Perspectives
|June 17, 2022
PubMed

Insights

Postoperative atrial fibrillation (AF) is a concern after coronary artery bypass graft (CABG) surgery. This case study observed five patients treated with dronedarone before CABG, noting their post-operative AF occurrence.

Area of Science:

  • Cardiology
  • Cardiac Surgery
  • Pharmacology

Background:

  • Atrial fibrillation (AF) is a common arrhythmia, particularly concerning post-coronary artery bypass graft (CABG) surgery.
  • Post-CABG AF increases risks of stroke, hospital readmission, and complicates anticoagulation management.
  • Dronedarone is an antiarrhythmic drug sometimes used in patients with cardiovascular conditions.

Observation:

  • This case study focused on five patients who received dronedarone before undergoing open-heart surgery (CABG).
  • The clinical course of these patients was monitored post-operatively.
  • Particular attention was paid to the development of atrial fibrillation after surgery.

Findings:

  • The study observed the incidence of post-operative atrial fibrillation in patients pre-treated with dronedarone.
  • Detailed patient outcomes regarding AF occurrence were recorded.

Implications:

  • Understanding dronedarone's effect on post-CABG AF is crucial for clinical decision-making.
  • This data may inform pre-operative medication strategies to mitigate AF risk.
  • Further research is warranted to confirm dronedarone's role in preventing post-CABG AF.

Keywords:
Atrial fibrillationCoronary artery bypass graftDronedaronePostoperative arrhythmia

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