Related Experiment Video
Updated: Sep 7, 2025
16:26
Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes
Published on: August 20, 2007
5.9K
Soluble RAGE Prevents Type 1 Diabetes Expanding Functional Regulatory T Cells
Sherman S Leung1,2, Danielle J Borg1,3, Domenica A McCarthy1
1Glycation and Diabetes, Mater Research, The University of Queensland and Translational Research Institute, Brisbane, Australia.
Diabetes
|June 17, 2022
Summary
Short-term administration of soluble receptor for advanced glycation end products (sRAGE) prevented murine diabetes by increasing regulatory T cells (Tregs). sRAGE treatment expanded functional human Tregs, highlighting its potential as a reproducible diabetes therapy.
Area of Science:
- Immunology
- Endocrinology
- Diabetes Research
Background:
- Type 1 diabetes is an autoimmune disease lacking a cure.
- The reproducibility crisis hinders clinical translation of potential diabetes therapeutics.
Purpose of the Study:
- To investigate the therapeutic potential of soluble receptor for advanced glycation end products (sRAGE) in preventing type 1 diabetes.
- To elucidate the mechanisms by which sRAGE impacts regulatory T cells (Tregs) and immune function in diabetes models.
Main Methods:
- Administration of sRAGE to mice in independent research centers.
- Assessment of Treg populations in islets, pancreatic lymph nodes, and spleen.
- Evaluation of Treg function in vitro using human Tregs and RAGE ligands.
- Utilized Treg depletion and RAGE knockout mouse models.
Main Results:
- sRAGE treatment protected against murine diabetes, with reproducible efficacy across two research centers.
- sRAGE administration increased the number and function of regulatory T cells (Tregs) within the pancreas and spleen.
- In vitro studies confirmed sRAGE expands functional human Tregs by reversing RAGE ligand-induced suppression.
- Diabetes protection was dependent on Tregs and RAGE antagonism.
Conclusions:
- sRAGE demonstrates reproducible efficacy in preventing experimental diabetes.
- sRAGE enhances Treg function and expansion, offering a promising therapeutic strategy.
- These findings position sRAGE as a potential treatment to prevent type 1 diabetes.
More Related Videos
Related Concept Videos
01:22Diabetes Mellitus: Overview and Type I Subtype
3.2K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
3.2K
01:24Glucagon-like Receptor Agonists
414
Incretins include glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which stimulate insulin secretion post-meals. In type 2 diabetes, GIP's efficacy is reduced, making GLP-1 a viable drug target. GIP originates from preproGIP.
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...
414
01:24T Cell Types and Functions
1.4K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.4K
01:22Diabetes Mellitus: Type 2 and Gestational
2.9K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.9K
01:19Psychoneuroimmunology: Diabetes and Cancer
61
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
61
01:36Carbohydrate Metabolism
11.6K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
11.6K