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ARTS, an unusual septin, regulates tumorigenesis by promoting apoptosis

Chenbin Bian1, Jing Su1, Zhuangzhuang Zheng1

  • 1Jilin Provincial Key Laboratory of Radiation Oncology & Therapy, The First Hospital of Jilin University, Changchun 130021, China; Department of Radiation Oncology, The First Hospital of Jilin University, Changchun 130021, China; NHC Key Laboratory of Radiobiology, School of Public Health, Jilin University, Changchun 130021, China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|June 17, 2022
PubMed

Insights

Apoptosis-related senescence (ARTS), a unique proapoptotic protein, inhibits tumor progression by targeting key antiapoptotic proteins. ARTS demonstrates significant tumor suppressor potential, offering new avenues for small-molecule drug development.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Oncology

Background:

  • Apoptosis is crucial in tumorigenesis, with antiapoptotic proteins promoting tumor progression.
  • The protein ARTS is the sole septin family member exhibiting proapoptotic function.
  • Tumorigenesis is closely linked to the expression of antiapoptotic proteins.

Purpose of the Study:

  • To review recent advances in the molecular mechanisms of ARTS in inhibiting tumorigenesis.
  • To explore the unique structural aspects of ARTS.
  • To discuss the therapeutic potential of mimicking ARTS for drug development.

Main Methods:

  • Literature review of recent advances in ARTS research.
  • Analysis of molecular mechanisms underlying ARTS' proapoptotic function.
  • Evaluation of ARTS' interaction with key apoptosis regulators (XIAP, Bcl-2, Bcl-XL).

Main Results:

  • ARTS possesses a unique structure and exhibits potent tumor suppressor capabilities.
  • ARTS directly inhibits XIAP and Bcl-2, and indirectly facilitates Bcl-XL degradation via p53.
  • ARTS' proapoptotic function is distinct from other known inhibitor of apoptosis protein (IAP) antagonists.

Conclusions:

  • ARTS is a promising target for cancer therapy due to its strong tumor suppressor potential.
  • Understanding ARTS' molecular mechanisms can guide the development of novel small-molecule drugs.
  • ARTS' unique structure and function offer a novel strategy for cancer treatment.
Keywords:
ARTSARTS mimeticsApoptosisBcl-2P53XIAP

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