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Diboronate crosslinking: Introducing glucose specificity in glucose-responsive dynamic-covalent networks
Yuanhui Xiang1, Sijie Xian1, Rachel C Ollier1
1University of Notre Dame, Department of Chemical & Biomolecular Engineering, Notre Dame, IN 46556, USA.
Summary
New diboronate hydrogels offer improved glucose binding and specificity for diabetes management. This dynamic-covalent chemistry enables more responsive insulin release and better blood glucose control.
Area of Science:
- Materials Science
- Biomedical Engineering
- Polymer Chemistry
Background:
- Dynamic-covalent chemistry enables self-healing and stimuli-responsive hydrogels.
- Aryl boronate-diol interactions are explored for glucose-responsive insulin delivery.
- Existing phenylboronic acid (PBA) approaches suffer from low glucose affinity and specificity.
Purpose of the Study:
- To develop novel dynamic-covalent hydrogels with enhanced glucose binding affinity and specificity.
- To improve glucose-responsive insulin release for diabetes management.
- To overcome limitations of traditional PBA-based glucose-responsive materials.
Main Methods:
- Synthesis of novel diboronate crosslinking motifs.
- Preparation of dynamic-covalent hydrogels using the diboronate chemistry.
- In vitro and in vivo evaluation of glucose-responsive insulin release and blood glucose control in a rodent diabetes model.
Main Results:
- The new diboronate hydrogels exhibit enhanced binding affinity and specificity for glucose compared to PBA-based hydrogels.
- Diboronate hydrogels demonstrate improved glucose-responsive insulin release with minimal interference from non-glucose analytes.
- Enhanced responsiveness led to more rapid blood glucose correction in a rodent model.
Conclusions:
- Novel diboronate dynamic-covalent crosslinking chemistry offers superior glucose binding and specificity.
- These diboronate hydrogels represent a significant advancement for sensitive and specific glucose-responsive materials.
- This approach holds promise for improved diabetes management through advanced insulin delivery systems.
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