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Effectiveness of an enhanced antibiotic stewardship programme among paediatric patients in a tertiary hospital in

H Q Nguyen1, H-Y Nguyen-Thi2, P-T Huynh3

  • 1Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam; School of Pharmacy, Queen's University Belfast, Belfast, UK.

The Journal of Hospital Infection
|June 17, 2022
PubMed

Insights

An enhanced antibiotic stewardship program (ASP) in Vietnam showed modest impact on pediatric antibiotic use. While improving Access antibiotic prescriptions and the Access-to-Watch ratio, it did not significantly reduce overall antibiotic consumption or improve clinical outcomes.

Area of Science:

  • Infectious Diseases
  • Pharmacology
  • Public Health

Background:

  • Vietnam's Ministry of Health promoted hospital antimicrobial stewardship in 2016.
  • Antibiotic resistance is a growing global health concern, necessitating effective stewardship programs.

Purpose of the Study:

  • To evaluate the effectiveness and safety of an enhanced antibiotic stewardship programme (ASP) compared to the original ASP.
  • The study focused on pediatric patients at a tertiary infectious diseases hospital in Vietnam.

Main Methods:

  • An interrupted time-series analysis examined antibiotic use in pediatric patients (0-17 years).
  • Data collected from April 2016 to March 2020 included defined daily doses (DDDs), days of therapy (DOT), WHO AWaRe classification, Access-to-Watch ratio, and clinical outcomes.
  • The study compared outcomes before and after the implementation of the enhanced ASP.

Main Results:

  • The enhanced ASP did not significantly alter antibiotic prescribing in DDDs or DOT.
  • A significant increase was observed in the percentage of Access antibiotics prescribed and the Access-to-Watch ratio.
  • No significant difference in worse clinical outcomes at discharge was found between the original and enhanced ASP.

Conclusions:

  • The enhanced ASP demonstrated a modest impact on pediatric antibiotic consumption.
  • Improvements in Access antibiotic use and the Access-to-Watch ratio were noted.
  • Further strategies may be needed to optimize antibiotic stewardship in this population.
Abstract

Keywords:
Antimicrobial stewardship programmePaediatricVietnam

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