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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

734
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
734
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

553
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
553
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

660
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
660

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Related Experiment Video

Updated: Sep 7, 2025

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
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Glaucoma Rose Plot Analysis: Detecting Early Structural Progression Using Angular Histograms.

Timothy E Yap1, Benjamin M Davis2, Philip A Bloom1

  • 1Western Eye Hospital, Imperial College Healthcare NHS Trust (ICHNT), London, United Kingdom; Imperial College Ophthalmic Research Group (ICORG), Imperial College London, United Kingdom.

Ophthalmology. Glaucoma
|June 17, 2022
PubMed
Summary
This summary is machine-generated.

Rose Plot Analysis (RPA) offers a novel, accurate method for detecting glaucoma progression. This technique improves interobserver agreement and aids in earlier diagnosis compared to traditional methods.

Keywords:
GlaucomaOCTProgression analysisRetinal nerve fiber layerRose plot

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Area of Science:

  • Ophthalmology
  • Medical Imaging Analysis

Background:

  • Glaucoma is a progressive optic neuropathy characterized by structural damage.
  • Accurate analysis of structural progression data is crucial for timely diagnosis and management.
  • Current methods for analyzing retinal imaging series may have limitations in interobserver agreement and early detection.

Purpose of the Study:

  • To evaluate the novel Rose Plot Analysis (RPA) for analyzing and presenting glaucoma structural progression data.
  • To compare the performance of RPA against established clinical imaging standards.

Main Methods:

  • A case-control image analysis study was conducted using retrospective spectral-domain OCT scans from open-angle glaucoma patients.
  • Rose Plot Analysis was developed using angular histograms and dynamic cluster analysis of circumpapillary retinal nerve fiber layer (cRNFL) data.
  • RPA plots were assessed by masked clinicians, and results were compared to a standard OCT series assessment with linear regression.

Main Results:

  • RPA demonstrated significantly greater interobserver agreement (κ=0.86) compared to standard OCT series assessment (κ=0.66).
  • The discriminative power of RPA (AUC=0.97) was superior to global cRNFL thickness and equivalent to sectoral cRNFL regression.
  • Progression was detected 8.7 months sooner with RPA than global cRNFL linear regression in progressing eyes.

Conclusions:

  • Rose Plot Analysis provides accurate and intuitive data analysis for glaucoma progression.
  • RPA enhances interobserver agreement and shows potential for earlier diagnosis of glaucomatous disease progression.