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Reproductive Organ Pathology of Individuals Undergoing Gender-Affirming Surgery
Justin T Kelley1, Emily R McMullen-Tabry2, Stephanie L Skala1
1Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Abstract:
As gender-affirming surgeries become more routine, it is increasingly important for pathologists to recognize the expected histologic changes seen in various tissues secondary to gender-affirming hormone therapy. For example, exogenous testosterone-related squamous atrophy or transitional cell metaplasia of the cervix may be confused for high-grade squamous intraepithelial lesion. In addition to distinguishing between benign and dysplastic/malignant features, pathologists should be mindful of the phrasing of their reports and aim to use objective, nongendered language.
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