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A role of insular cortex in cardiovascular function.

D A Ruggiero, S Mraovitch, A R Granata

    The Journal of Comparative Neurology
    |March 8, 1987
    PubMed
    Summary
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    This study shows the insular cortex regulates arterial blood pressure (AP) and heart rate. Electrical and chemical stimulation of the insular cortex in rats increased AP and heart rate.

    Area of Science:

    • Neuroscience
    • Cardiovascular Physiology
    • Autonomic Nervous System Regulation

    Background:

    • The insular cortex's role in cardiovascular regulation is not fully understood.
    • Investigating neural pathways controlling arterial blood pressure (AP) is crucial for understanding cardiovascular homeostasis.

    Purpose of the Study:

    • To determine if the insular cortex contributes to the regulation of arterial blood pressure (AP).
    • To map the specific areas within the insular cortex involved in cardiovascular control.

    Main Methods:

    • Anatomical tracing using wheat germ agglutinin-horseradish peroxidase (WGA-HRP) to identify insular cortex projections to the nucleus tractus solitarii (NTS).
    • Electrical and chemical stimulation (L-Glu, kainic acid) of the insular cortex in anesthetized rats.

    Related Experiment Videos

  • Monitoring of arterial blood pressure (AP) and heart rate responses.

    • Main Results:

    • Electrical stimulation of the insular cortex elicited significant elevations in AP and heart rate.
    • Chemical stimulation with L-Glu and kainic acid in specific insular cortex regions caused dose-dependent increases in AP and tachycardia.
    • Anatomical studies revealed complex topographic organization of insular cortex projections to the NTS, including overlap with baroreceptor afferent fields.

    Conclusions:

    • Neurons in the insular cortex project to brainstem autonomic nuclei, including the NTS.
    • Activation of these insular cortex neurons leads to increased arterial blood pressure and heart rate.
    • The insular cortex plays a significant role in the central regulation of cardiovascular function.