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Experiencing social exclusion changes gut microbiota composition.

Chong-Su Kim1, Go-Eun Shin2, Yunju Cheong1

  • 1Department of Food and Nutrition, College of Human Ecology, Seoul National University, Seoul, 08826, Republic of Korea.

Translational Psychiatry
|June 17, 2022
PubMed
Summary
This summary is machine-generated.

Social exclusion intensifies psychological pain and anxiety, altering gut microbiota composition. Specific microbial changes, like reduced Faecalibacterium, correlate with social exclusion experiences, suggesting new therapeutic targets.

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Area of Science:

  • Neuroscience
  • Microbiology
  • Psychology

Background:

  • The gut-brain axis links gut microbiota to host mental health.
  • Social exclusion is a significant stressor with psychological consequences.

Purpose of the Study:

  • To investigate the relationship between gut microbiome composition and psychological pain experienced during social exclusion.
  • To identify specific microbial alterations associated with social exclusion.

Main Methods:

  • Assessed psychological status using Beck Anxiety Inventory (BAI), Beck Depression Inventory, and UCLA Loneliness Scale.
  • Analyzed gut microbiota composition using 16S rRNA gene sequencing and bioinformatics.
  • Compared microbial profiles between individuals with and without social exclusion experiences.

Main Results:

  • Individuals experiencing social exclusion reported higher anxiety and psychological pain (higher BAI scores).
  • Significant differences in gut microbial profiles were observed, including a higher prevalence of Prevotella and reduced Firmicutes/Bacteroidetes ratio in the exclusion group.
  • Decreased abundance of Faecalibacterium spp. was associated with the duration and intensity of social exclusion.

Conclusions:

  • Psychological pain from social exclusion is significantly correlated with gut microbiota composition.
  • Targeting specific microorganisms involved in social exclusion may offer novel therapeutic strategies for psychological issues and social problems.