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OBGYN providers' lack of knowledge and management of genetic risks due to advanced paternal age underscore the need

Joseph F Biddle1,2, Leah Wetherill3, Gabrielle C Geddes1

  • 1Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.

Journal of Community Genetics
|June 17, 2022
PubMed

Insights

Healthcare providers, especially OBGYNs, show knowledge gaps regarding advanced paternal age (APA) risks and guidelines. Updated education and visible guidelines are needed for better management of APA-associated conditions.

Area of Science:

  • Reproductive Medicine
  • Genetics
  • Healthcare Professional Education

Background:

  • Advanced paternal age (APA) is increasingly common.
  • Understanding of APA risks and management varies among healthcare providers.
  • Current clinical practices regarding APA require characterization.

Purpose of the Study:

  • To assess healthcare professionals' knowledge of advanced paternal age (APA).
  • To evaluate awareness of APA-associated risks and current clinical practices.
  • To identify gaps in knowledge and areas for improved clinical guidance.

Main Methods:

  • An online survey was distributed to healthcare providers.
  • Participants included specialists in medical genetics (GEN), maternal fetal medicine (MFM), and obstetrics and gynecology (OBGYN).
  • Survey assessed demographic information, APA knowledge, guideline familiarity, and clinical practices.

Main Results:

  • 67 providers responded; 54 were physicians (GEN, MFM, OBGYN).
  • OBGYNs demonstrated lower agreement on APA-genetic disease links and more misconceptions about risks compared to GEN and MFM.
  • Most physicians were unaware of recent APA guidelines, with OBGYNs showing significant knowledge gaps.

Conclusions:

  • Healthcare providers, particularly OBGYNs, require enhanced education on advanced paternal age risks.
  • Updated and more accessible guidelines for APA management are recommended for GEN, MFM, and OBGYN specialists.
  • Targeted educational materials could address specific knowledge deficits in OBGYNs regarding APA.

Keywords:
Advanced paternal ageGenetic diseaseMaternal-fetal medicineObstetrics and gynecologyProfessional guidelines

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