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Predictive value of LDL/HDL ratio in coronary atherosclerotic heart disease

Ting Sun1, Mengyun Chen2, Huanhuan Shen3

  • 1Department of Cardiology, Shanghai Ninth People's Hospital Affiliated With Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, People's Republic of China. beibeisun2008@163.com.

BMC Cardiovascular Disorders
|June 17, 2022
PubMed

Insights

The LDL/HDL ratio may be a superior predictor of coronary atherosclerotic heart disease (CAHD) severity compared to LDL-C or HDL-C alone. This ratio showed a stronger association with CAHD prevalence and severity in patients with myocardial ischemia.

Area of Science:

  • Cardiology
  • Biochemistry

Background:

  • Dyslipidemia is a significant risk factor for coronary atherosclerotic heart disease (CAHD).
  • Assessing the predictive power of lipid ratios versus individual lipid components is crucial for cardiovascular risk stratification.

Purpose of the Study:

  • To evaluate the efficacy of the LDL/HDL ratio in predicting the severity of CAHD.
  • To compare the predictive performance of the LDL/HDL ratio against LDL-C and HDL-C alone.

Main Methods:

  • A retrospective analysis of 1351 patients with myocardial ischemia undergoing coronary angiography.
  • Statistical analyses including Spearman correlation, logistic regression, Cox proportional hazards model, and multicollinearity were employed.
  • Evaluation of LDL/HDL ratio's predictive capability for CAHD severity in comparison to LDL-C and HDL-C.

Main Results:

  • Patients with CAHD exhibited a higher LDL/HDL ratio (2.94±1.06) compared to controls (2.36±0.78).
  • The LDL/HDL ratio demonstrated a stronger association with coronary vascular stenosis severity (AUC=0.668) than LDL-C (AUC=0.574) or HDL-C (AUC=0.625).
  • A higher LDL/HDL ratio was significantly related to CAHD prevalence (OR=2.39).

Conclusions:

  • The LDL/HDL ratio may serve as a more effective predictor of CAHD severity.
  • This ratio offers improved risk assessment for coronary atherosclerotic heart disease compared to traditional lipid measures.
Abstract

Keywords:
Coronary atherosclerotic heart diseaseLDL/HDL ratioRisks

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