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Long non-coding RNA MIR4435-2HG: a key molecule in progression of cancer and non-cancerous disorders

Majid Ghasemian1, Masoumeh Rajabibazl2, Unes Sahebi1

  • 1Department of Clinical Biochemistry, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Cancer Cell International
|June 17, 2022
PubMed

Insights

The long non-coding RNA MIR4435-2HG (LINC00978) functions as an oncogene in cancers and is implicated in non-cancerous conditions. This review explores its roles as a potential biomarker and therapeutic target.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • MIR4435-2HG (LINC00978) is a long non-coding RNA (lncRNA) with oncogenic roles in various cancers.
  • This lncRNA is also involved in non-cancerous conditions like cardiovascular and bone diseases.

Purpose of the Study:

  • To review the multifaceted roles of lncRNA MIR4435-2HG in both cancerous and non-cancerous diseases.
  • To highlight its potential as a diagnostic biomarker and therapeutic target.

Main Methods:

  • Literature review of studies investigating MIR4435-2HG.
  • Analysis of its molecular mechanisms, including apoptosis inhibition, miRNA sponging, and cell signaling pathway regulation.

Main Results:

  • MIR4435-2HG promotes cancer progression through mechanisms like enhanced proliferation, invasion, migration, and epithelial-mesenchymal transition (EMT).
  • It influences key signaling pathways such as Wnt, TGF-β/SMAD, Nrf2/HO-1, PI3K/AKT, MAPK/ERK, and FAK/AKT/β‑catenin.
  • Evidence suggests its involvement in diverse pathologies beyond cancer.

Conclusions:

  • MIR4435-2HG is a significant player in multiple disease states, acting as an oncogene and contributing to other disorders.
  • Its regulatory functions and involvement in critical pathways position it as a promising biomarker and therapeutic target for future research and clinical applications.
Keywords:
BiomarkerCancerMIR4435-2HGlncRNA

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