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Description of a European memory clinic cohort undergoing amyloid-PET: The AMYPAD Diagnostic and Patient Management
Daniele Altomare1,2, Lyduine Collij3, Camilla Caprioglio1,2
1Laboratory of Neuroimaging of Aging (LANVIE), University of Geneva, Geneva, Switzerland.
Introduction:
AMYPAD Diagnostic and Patient Management Study (DPMS) aims to investigate the clinical utility and cost-effectiveness of amyloid-PET in Europe. Here we present participants' baseline features and discuss the representativeness of the cohort.
Methods:
Participants with subjective cognitive decline plus (SCD+), mild cognitive impairment (MCI), or dementia were recruited in eight European memory clinics from April 16, 2018, to October 30, 2020, and randomized into three arms: ARM1, early amyloid-PET; ARM2, late amyloid-PET; and ARM3, free-choice.
Results:
A total of 840 participants (244 SCD+, 341 MCI, and 255 dementia) were enrolled. Sociodemographic/clinical features did not differ significantly among recruiting memory clinics or with previously reported cohorts. The randomization assigned 35% of participants to ARM1, 32% to ARM2, and 33% to ARM3; cognitive stages were distributed equally across the arms.
Discussion:
The features of AMYPAD-DPMS participants are as expected for a memory clinic population. This ensures the generalizability of future study results.
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