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Chemistry solutions to facilitate nanopore detection and analysis
Liang Wang1, Han Wang1, Xiaohan Chen1
1Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing, 400714, China; Chongqing School, University of Chinese Academy of Sciences, Chongqing, 400714, China.
Biosensors & Bioelectronics
|June 18, 2022
Summary
Chemistry solutions enhance nanopore sensing for analyzing molecules. These methods improve detection sensitivity and selectivity, enabling better molecular analysis in complex systems.
Area of Science:
- Nanotechnology
- Analytical Chemistry
- Molecular Biology
Background:
- Single-molecule nanopore analysis generates ionic current modulations, revealing molecular length, composition, and structure.
- Challenges remain in achieving high resolution for analyte observation and quantification in complex biological samples.
Purpose of the Study:
- To review recent advancements in using chemistry solutions to improve nanopore detection and analysis.
- To highlight various chemical strategies that enhance nanopore sensing capabilities.
Main Methods:
- Categorization of chemistry solutions: covalent/non-covalent, redox, displacement, back titration, chelation, hydrolysis, and click chemistry.
- Discussion of how these chemical reactions assist nanopore sensing.
Main Results:
- Chemical reaction-assisted nanopore sensing significantly improves sensor sensitivity and selectivity.
- These strategies enable detailed study of molecular properties and interactions.
Conclusions:
- Chemistry solutions are crucial for advancing nanopore detection and analysis.
- Future applications may integrate non-chemistry based methods with nanopore sensors for interdisciplinary research.
