Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Metastasis02:30

Metastasis

5.7K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.7K
Tumor Progression02:07

Tumor Progression

6.5K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.5K
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

3.1K
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
3.1K
Functions of the Lymphatic and Immune System01:28

Functions of the Lymphatic and Immune System

4.1K
The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
4.1K
The Tumor Microenvironment02:17

The Tumor Microenvironment

6.8K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.8K
Detailed Structure and Function of Lymph Nodes01:23

Detailed Structure and Function of Lymph Nodes

2.4K
Lymph nodes are bean-shaped structures that cluster along the lymphatic vessels in the inguinal, axillary, and cervical regions. Each node is divided into compartments by a capsule that extends trabeculae inward.
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...
2.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lymphatic egress recycles tumor-experienced effector CD8 T cells to sustain immune surveillance.

bioRxiv : the preprint server for biology·2026
Same author

A tumor metabolism-angiogenesis-immune axis governs immunotherapy responses.

bioRxiv : the preprint server for biology·2026
Same author

Targeting DNA Polymerase Epsilon Induces Tumor Clearance and Activates an NF-κB-Mediated Inflammatory Response in Triple Negative Breast Cancer.

Cancer research·2026
Same author

Peripheral immune-inducer dendritic cells drive early-life allergic inflammation.

Nature·2026
Same author

Chromatin architecture and physical constriction cooperate in phenotype switching and cancer cell dissemination.

bioRxiv : the preprint server for biology·2026
Same author

Transcription factor Etv3 controls the tolerogenic function of dendritic cells.

Science (New York, N.Y.)·2026
Same journal

Itaconate in cancer immunity: Evidence, ambiguities, and translational barriers.

Trends in cancer·2026
Same journal

Patient-derived organoids in hematologic malignancies: Fidelity and translation beyond animals.

Trends in cancer·2026
Same journal

Precision neuro-oncology for children: Time to gear up!

Trends in cancer·2026
Same journal

Multi-omics analysis of extracellular vesicle cargo in cancer.

Trends in cancer·2026
Same journal

An immunological panacea for cancer-related cachexia.

Trends in cancer·2026
Same journal

Beyond one gene, one target: Next-generation precision oncology.

Trends in cancer·2026
See all related articles

Related Experiment Video

Updated: Sep 7, 2025

Quantification of Tumor Cell Adhesion in Lymph Node Cryosections
06:09

Quantification of Tumor Cell Adhesion in Lymph Node Cryosections

Published on: February 9, 2020

12.3K

Lymph node metastasis fuels systemic disease.

Katherine S Ventre1, Triantafyllia Karakousi1, Amanda W Lund2

  • 1Ronald O. Perelman Department of Dermatology, New York University (NYU) Grossman School of Medicine, New York, NY, USA.

Trends in Cancer
|June 18, 2022
PubMed
Summary
This summary is machine-generated.

Lymph node metastasis is enhanced by evading natural killer (NK) cell control and interferon (IFN) adaptation. These metastases then promote further tumor spread by expanding systemic tolerance.

Keywords:
NK cellsinterferonslymph node metastasissystemic tolerance

More Related Videos

Author Spotlight: A Model to Study the Systemic and Local Dynamics of CD8+ T Cells During LN Metastasis
07:45

Author Spotlight: A Model to Study the Systemic and Local Dynamics of CD8+ T Cells During LN Metastasis

Published on: January 26, 2024

2.1K
Author Spotlight: Decoding Metastasis-to-Metastasis Seeding Using a New In Vivo Technique for Tracking Breast Cancer Spread
05:23

Author Spotlight: Decoding Metastasis-to-Metastasis Seeding Using a New In Vivo Technique for Tracking Breast Cancer Spread

Published on: July 7, 2023

1.2K

Related Experiment Videos

Last Updated: Sep 7, 2025

Quantification of Tumor Cell Adhesion in Lymph Node Cryosections
06:09

Quantification of Tumor Cell Adhesion in Lymph Node Cryosections

Published on: February 9, 2020

12.3K
Author Spotlight: A Model to Study the Systemic and Local Dynamics of CD8+ T Cells During LN Metastasis
07:45

Author Spotlight: A Model to Study the Systemic and Local Dynamics of CD8+ T Cells During LN Metastasis

Published on: January 26, 2024

2.1K
Author Spotlight: Decoding Metastasis-to-Metastasis Seeding Using a New In Vivo Technique for Tracking Breast Cancer Spread
05:23

Author Spotlight: Decoding Metastasis-to-Metastasis Seeding Using a New In Vivo Technique for Tracking Breast Cancer Spread

Published on: July 7, 2023

1.2K

Area of Science:

  • Oncology
  • Immunology
  • Cancer Biology

Background:

  • The role of lymph node (LN) metastasis in systemic tumor progression remains debated.
  • Understanding the mechanisms driving LN metastasis is crucial for improving cancer patient outcomes.

Purpose of the Study:

  • To investigate how cancer cells overcome immune surveillance to establish LN metastasis.
  • To elucidate the impact of LN metastases on systemic immunity and further tumor dissemination.

Main Methods:

  • The study likely involved in vivo models and in vitro assays to track cancer cell behavior.
  • Analysis of immune cell interactions, specifically natural killer (NK) cells and interferon (IFN) signaling pathways.
  • Assessment of systemic immune responses and distant organ metastasis formation.

Main Results:

  • Cancer cells sequentially evade NK cell surveillance and undergo IFN-dependent epigenetic changes to facilitate LN metastasis.
  • Established LN metastases induce systemic peripheral tolerance, creating an immunosuppressive environment.
  • LN metastasis significantly promotes the development of distant organ metastases.

Conclusions:

  • Evasion of innate immunity and epigenetic reprogramming are key steps in LN metastasis.
  • LN metastases actively shape the systemic immune landscape to promote further cancer spread.
  • Targeting these mechanisms could offer novel therapeutic strategies against metastatic cancer.