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Updated: Sep 7, 2025
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Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs
Published on: August 8, 2022
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Development of Biodegradable Osteopromotive Citrate-Based Bone Putty.
Xinyu Tan1,2,3, Ethan Gerhard2, Yuqi Wang2
1Department of Cell Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong Province, 510515, China.
Small (Weinheim an Der Bergstrasse, Germany)
|June 19, 2022
Summary
A novel citrate-based polymer/hydroxyapatite putty offers a multi-functional solution for bone fractures and bleeding. This innovative biomaterial promotes bone regeneration, controls bleeding, and exhibits antimicrobial properties, outperforming traditional bone wax.
Area of Science:
- Biomaterials Science
- Orthopedic Surgery
- Polymer Chemistry
Background:
- Bone fractures and noncompressible bleeding necessitate advanced biomaterials.
- Current bone wax is nondegradable, impeding healing and increasing infection risk.
Purpose of the Study:
- To design and evaluate a novel, multi-functional citrate-based polymer/hydroxyapatite (BPLP-Ser/HA) composite putty.
- To address challenges in bone regeneration, hemostasis, and infection control.
Main Methods:
- Developed intrinsically fluorescent, osteopromotive BPLP-Ser/HA putty.
- Characterized mechanical properties, degradation, swelling, hemostasis, and bone adhesion.
- Assessed in vitro antimicrobial activity and in vivo bone regeneration in a rat calvaria model.
Main Results:
- BPLP-Ser/HA putty mimics early bone mechanics, strengthens upon hydration, and has tunable degradation.
- Demonstrated excellent hemostatic potential (>24h resistance to blood pressure) and bone adhesion.
- Showed significant antimicrobial effects and in vivo bone regeneration comparable to autograft.
Conclusions:
- BPLP-Ser/HA putty is a promising off-the-shelf solution for acute wound management and bone regeneration.
- The putty effectively addresses osseous hemorrhage, infection, and nonunion complications.
- This biomaterial offers a superior alternative to conventional bone wax for orthopedic applications.
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