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Related Experiment Video

Updated: Sep 7, 2025

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus

Published on: March 8, 2015

Deep Brain Stimulation for Chronic Pain.

Alexander Alamri¹, Erlick A C Pereira¹

¹Neurosciences Research Centre, Molecular and Clinical Sciences Institute, St George's University of London, London, United Kingdom.

Neurosurgery Clinics of North America

|June 19, 2022

Summary

This summary is machine-generated.

Deep brain stimulation (DBS) offers a neurosurgical treatment for movement disorders, epilepsy, and psychiatric conditions. Pioneered in the 1950s, DBS also effectively treats various chronic pain states by targeting specific brain regions.

Keywords:

Anterior cingulate cortex Chronic pain Deep brain stimulation Periaqueductal gray/periventricular gray Ventral posterior thalamus

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Area of Science:

Neurosurgery
Neurology
Pain Management

Background:

Deep brain stimulation (DBS) is an established neurosurgical technique.
DBS is primarily recognized for treating movement disorders, epilepsy, Tourette syndrome, and obsessive-compulsive disorders.
Its application extends to managing various chronic pain conditions.

Purpose of the Study:

To review the historical development and therapeutic applications of DBS.
To highlight DBS as a treatment modality for diverse pain conditions.
To identify key neuroanatomical targets utilized in DBS for pain management.

Main Methods:

Literature review of DBS applications.
Analysis of historical data and clinical studies.
Identification of neuroanatomical targets for pain treatment.

Main Results:

DBS was first developed in the 1950s.
Established efficacy in movement disorders and psychiatric conditions.
Demonstrated utility in treating facial pain, phantom limb pain, post-stroke pain, and brachial plexus pain.

Conclusions:

Deep brain stimulation (DBS) is a versatile neurosurgical intervention with a long history.
DBS is effective not only for neurological and psychiatric disorders but also for intractable pain.
Targeting specific brain areas like the sensory thalamus, PAG, PVG, and ACC is crucial for successful pain relief with DBS.