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Updated: Apr 13, 2026

Free Radicals in Chemical Biology: from Chemical Behavior to Biomarker Development
Published on: April 15, 2013
Reaction mechanisms of peroxyl and C-centered radicals with sulfhydryls
Abstract:
Rate constants for reactions of a peroxyl (CCl3OO.) and C-centered radicals, that is, phenyl (.C6H4CH2COO-) and vinyl (uracil-5-yl), with an aromatic thiol (p-CH3OC6H4SH) were measured over a pH range (3-12) to include ArSH and ArS- forms. The pH dependence of these rate constants indicates that peroxyl radicals react by a redox mechanism while the C-centered radicals react by an H-atom transfer process. The different mechanisms encountered in the repair of various radicals suggest design features to be incorporated into antiagents, such as radioprotectors and anticarcinogens.
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