Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

24
During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
24
Cardiomyopathy VII: Pre and Post Operative Nursing Management01:28

Cardiomyopathy VII: Pre and Post Operative Nursing Management

27
Patients with hypertrophic cardiomyopathy (HCM) and left ventricular outflow tract (LVOT) obstruction who remain symptomatic despite optimal medical therapy may undergo a septal myectomy (Morrow procedure). This procedure involves excising a portion of the hypertrophied septum below the aortic valve using a heart-lung machine to improve blood flow through the LVOT. Effective preoperative and postoperative nursing management ensures successful patient outcomes, minimizes complications, and...
27
General Anesthesia: Overview01:24

General Anesthesia: Overview

282
Anesthesia is a medical procedure that uses drugs for CNS suppression to enable painless surgeries and procedures. The selection of anesthetics is influenced by their pharmacokinetic properties, side effects, and patient characteristics. Various types of anesthesia include general, local, regional, spinal, and inhalational.
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
282
Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy01:26

Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy

167
Sigmoidoscopy and laparoscopy are distinct medical procedures that enable physicians to internally inspect different parts of the GI tract. Although they serve different purposes, each is essential for diagnosing and, in some cases, treating various medical conditions.
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
167
Stages of General Anesthesia01:22

Stages of General Anesthesia

673
Various sedation levels offer significant advantages in facilitating procedural interventions for patients undergoing medical or invasive surgical procedures. These levels span from anxiolysis to general anesthesia, providing a spectrum of sedative effects to cater to specific patient needs. Anxiolysis reduces anxiety and is achieved through minimal sedation, enabling patients to remain awake and responsive while feeling more at ease during the procedure. This level can benefit minor...
673
Aneurysm IV: Nursing Management01:22

Aneurysm IV: Nursing Management

19
Vigilant monitoring for aneurysm rupture is essential for patients undergoing aortic surgery.Preoperative Nursing ManagementContinuously monitor the patient for manifestations of aneurysm rupture, such as pallor, weakness, tachycardia, hypotension, abdominal, back, groin, or periumbilical pain, changes in consciousness, and a pulsating abdominal mass. Regularly assess the patient's peripheral pulses.Instruct the patient to consume a clear liquid diet the day before surgery and administer...
19

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Therapeutic targeting of fibrin-microglia interactions ameliorates Alzheimer's disease-related hyperexcitability and brain network dysfunction.

bioRxiv : the preprint server for biology·2026
Same author

Resilience to neuronal hyperactivity and restoration of the neuroimmune interactome by blocking fibrin-induced microglia activation in Alzheimers disease.

bioRxiv : the preprint server for biology·2026
Same author

Dynamics of neutrophilia at the neurovascular unit arising from repeated pulmonary inflammation.

Journal of neuroinflammation·2026
Same author

Electrical stimulation of the vagus nerve improves amyloid pathology in delirium superimposed on dementia.

Bioelectronic medicine·2026
Same author

Biomarkers.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Basic Science and Pathogenesis.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025

Related Experiment Video

Updated: Sep 7, 2025

A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration
08:17

A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration

Published on: February 27, 2018

16.5K

Breaking barriers in postoperative delirium.

Niccolò Terrando1, Katerina Akassoglou2

  • 1Department of Anesthesiology, Cell Biology, and Immunology, Duke University Medical Center, Durham, NC, USA.

British Journal of Anaesthesia
|June 19, 2022
PubMed
Summary
This summary is machine-generated.

Peripheral surgical trauma can trigger brain changes, including inflammation and cognitive issues. A study in the British Journal of Anaesthesia highlights blood-brain barrier dysfunction and neuroinflammation in patients experiencing postoperative delirium.

Keywords:
biomarkerblood–brain barriercerebrospinal fluiddeliriumfibrinogenneuroinflammation

More Related Videos

Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery
12:04

Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery

Published on: January 6, 2011

13.1K
A Bedside, Single Burr Hole Approach to Multimodality Monitoring in Severe Brain Injury
06:18

A Bedside, Single Burr Hole Approach to Multimodality Monitoring in Severe Brain Injury

Published on: March 26, 2019

9.1K

Related Experiment Videos

Last Updated: Sep 7, 2025

A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration
08:17

A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration

Published on: February 27, 2018

16.5K
Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery
12:04

Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery

Published on: January 6, 2011

13.1K
A Bedside, Single Burr Hole Approach to Multimodality Monitoring in Severe Brain Injury
06:18

A Bedside, Single Burr Hole Approach to Multimodality Monitoring in Severe Brain Injury

Published on: March 26, 2019

9.1K

Area of Science:

  • Neuroscience
  • Immunology
  • Gerontology

Background:

  • Systemic perturbations like surgical trauma impact neurovascular and inflammatory processes.
  • The blood-brain barrier (BBB) is crucial for neuroimmune homeostasis, regulating central nervous system responses.
  • BBB dysfunction is implicated in aging and neurological disorders such as Alzheimer's disease.

Discussion:

  • A recent study investigated BBB alterations and neuroinflammation in patients with postoperative delirium.
  • The research focused on non-intracranial surgery patients, linking peripheral trauma to central nervous system changes.
  • Postoperative delirium is associated with significant neuroinflammatory markers and BBB compromise.

Key Insights:

  • Peripheral surgical trauma can lead to significant blood-brain barrier changes.
  • Neuroinflammation is a key component in the development of postoperative delirium.
  • The study underscores the BBB's role as a critical interface affected by systemic stress.

Outlook:

  • Further research is needed to understand the precise mechanisms linking BBB dysfunction to delirium.
  • Therapeutic strategies targeting the BBB could potentially mitigate cognitive decline post-surgery.
  • Investigating BBB integrity may offer new diagnostic or prognostic markers for neurological complications.