Related Experiment Video

Updated: Sep 7, 2025

Characterizing RNA Modifications in Single Neurons Using Mass Spectrometry
08:45

Characterizing RNA Modifications in Single Neurons Using Mass Spectrometry

Published on: April 21, 2022

2.5K

Regulation and roles of RNA modifications in aging-related diseases

Zeyidan Jiapaer1,2, Dingwen Su3, Lingyang Hua4

  • 1College of Life Science & Technology, Xinjiang University, Urumqi, China.

Aging Cell
|June 20, 2022
PubMed

Insights

RNA modifications are dynamically regulated and play a critical role in aging and related diseases. Understanding these changes offers new avenues for diagnostics and therapeutics for age-related conditions.

Area of Science:

  • Molecular Biology
  • Gerontology
  • Epigenetics

Background:

  • The global population is aging, increasing focus on delaying aging and age-related diseases.
  • RNA modifications, once considered static, are now known to be dynamic regulators of cellular processes, including aging.
  • Emerging evidence links RNA modifications to cellular senescence and the aging process.

Purpose of the Study:

  • To review current knowledge on RNA modifications and their roles in aging.
  • To catalog RNA modifications across various RNA species (mRNAs, miRNAs, lncRNAs, tRNAs, rRNAs).
  • To focus on the regulation and involvement of RNA modifications in specific aging-related diseases.

Main Methods:

  • Literature review of current research on RNA modifications and aging.
  • Compilation of a catalog of known RNA modifications.
  • Analysis of the functional roles of RNA modifications in aging and disease pathogenesis.

Main Results:

  • RNA modifications are widespread across RNA species and dynamically regulated.
  • These modifications are critically involved in cellular senescence and the aging process.
  • Specific RNA modifications are implicated in neurodegenerative, cardiovascular, and other age-related diseases.

Conclusions:

  • Understanding RNA modifications is crucial for comprehending fundamental aging mechanisms.
  • This knowledge facilitates the development of novel diagnostics and therapeutics for age-related diseases.
  • Targeting RNA modifications presents a promising strategy for combating aging and its associated pathologies.
Keywords:
RNA modificationagingaging-related diseaseepitranscriptome

More Related Videos

Investigation of RNA Synthesis Using 5-Bromouridine Labelling and Immunoprecipitation09:59

Investigation of RNA Synthesis Using 5-Bromouridine Labelling and Immunoprecipitation

Published on: May 3, 2018

9.6K
A Method for Measuring RNA N6-methyladenosine Modifications in Cells and Tissues08:56

A Method for Measuring RNA N6-methyladenosine Modifications in Cells and Tissues

Published on: December 5, 2016

11.0K

Related Concept Videos

RNA Stability01:53

RNA Stability

Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
33.9K
Regulation of Expression at Multiple Steps01:23

Regulation of Expression at Multiple Steps

The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the...
994
Nuclear Export of mRNA02:31

Nuclear Export of mRNA

Before mRNAs are exported to the cytoplasm, it is crucial to check each mRNA for structural and functional integrity. Eukaryotic cells use several different mechanisms, collectively known as mRNA surveillance, to look for irregularities in mRNAs. Irregular or aberrant mRNA are rapidly degraded by various enzymes. If a defective mRNA escapes the surveillance, it would be translated into a protein which would either be non-functional or not function properly. One of the primary irregularities in...
7.8K
Regulation of Expression Occurs at Multiple Steps02:24

Regulation of Expression Occurs at Multiple Steps

Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
23.2K
Chromatin Structure Regulates pre-mRNA Processing02:41

Chromatin Structure Regulates pre-mRNA Processing

In eukaryotic cells, nascent mRNA transcripts need to undergo many post-transcriptional modifications to reach the cell cytoplasm and translate into functional proteins. For a long time, transcription and pre-mRNA processing were considered two independent events that occur sequentially in the cell. However, it has now been well established that transcription and pre-mRNA processing are two simultaneous processes that are precisely regulated inside the cell.
The chromatin structure, especially...
7.2K
RNA Editing02:23

RNA Editing

RNA editing is a post-transcriptional modification where a precursor mRNA (pre-mRNA) nucleotide sequence is changed by base insertion, deletion, or modification. The extent of RNA editing varies from a few hundred bases, in mitochondrial DNA of trypanosomes, to a just single base, in nuclear genes of mammals. Even a single base change in the pre-mRNA can convert a codon for one amino acid into the codon for another amino acid or a stop codon. This type of re-coding can significantly affect the...
9.2K