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Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
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Emerging Role of miRNAs in the Pathogenesis of Periodontitis

Mohammad Taheri1, Tayyebeh Khoshbakht2, Bashdar Mahmud Hussen3,4

  • 1Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Current Stem Cell Research & Therapy
|June 20, 2022
PubMed

Insights

MicroRNAs (miRNAs) are involved in immune system regulation and are dysregulated in periodontitis. This review details how altered miRNA expression impacts the development and progression of this gum disease.

Area of Science:

  • Immunology
  • Molecular Biology
  • Genetics

Background:

  • MicroRNAs (miRNAs) regulate gene expression and are implicated in immune-related diseases.
  • Periodontitis, a chronic inflammatory gum disease, is associated with the dysregulation of specific miRNAs.
  • Numerous miRNAs, including the let-7 family, miR-125, and miR-146, show altered levels in periodontitis patients.

Approach:

  • This review synthesizes current research on the role of miRNA dysregulation in periodontitis.
  • It examines how specific miRNAs affect the expression of immune-related genes and molecules.
  • The focus is on understanding the impact of these molecular changes on the disease's pathoetiology.

Key Points:

  • miRNA dysregulation is a significant factor in the pathogenesis of periodontitis.
  • miR-146 is frequently upregulated in periodontitis patients, making it a key miRNA of interest.
  • Altered miRNA levels influence cytokine production and immune cell activity, contributing to disease progression.

Conclusions:

  • miRNAs play a crucial role in the immune response within the context of periodontitis.
  • Understanding miRNA dysregulation offers potential therapeutic targets for periodontitis.
  • Further research into specific miRNA functions can elucidate mechanisms driving immune dysregulation in this condition.
Keywords:
MicroRNAbiomarkerdiagnoseexpressionpathogenesis.periodontitis

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