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Updated: Sep 7, 2025

Quantitative 3D In Silico Modeling q3DISM of Cerebral Amyloid-beta Phagocytosis in Rodent Models of Alzheimer's Disease
Published on: December 26, 2016
Gastrointestinal Changes and Alzheimer's Disease.
Mona Sohrabi1, Bijayani Sahu1, Harpreet Kaur1
1Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58202-9037, USA.
Alzheimer's disease (AD) involves changes throughout the gastrointestinal tract, not just the brain. These gut changes may influence brain function and AD progression, highlighting a systemic aspect of the disease.
Area of Science:
- Neuroscience
- Gastroenterology
- Immunology
Background:
- A bidirectional communication pathway exists between the brain and the gastrointestinal system.
- Dysfunction in one organ system can impact the other, suggesting a systemic influence of disease.
Purpose of the Study:
- To investigate if inflammatory or degenerative changes in the gastrointestinal system are characteristic of Alzheimer's disease (AD).
Main Methods:
- A comprehensive review of existing rodent and human studies was conducted.
- Studies focusing on gastrointestinal alterations in the context of Alzheimer's disease were analyzed.
Main Results:
- Alzheimer's disease pathology extends beyond the brain to affect the gastrointestinal tract at multiple levels.
- Both immune and neuronal changes in the gut are implicated in Alzheimer's disease.
- Gastrointestinal conditions may communicate with the brain, influencing disease development and progression.
Conclusions:
- Gastrointestinal changes are an underrecognized facet of Alzheimer's disease.
- Alzheimer's disease exerts a systemic influence, involving the gastrointestinal system significantly.
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