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Pirprofen-associated hepatic injury.

W W De Herder, P Schröder, A Purnode

Journal of Hepatology

|February 1, 1987

Summary

Pirprofen (Rengasil) can cause severe liver injury, including hepatocellular damage and necrosis, in rare cases. This unpredictable reaction may be due to metabolic idiosyncrasies, leading to fatalities or incomplete recovery.

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Area of Science:

Hepatology
Clinical Pharmacology
Toxicology

Background:

Pirprofen, a non-steroidal anti-inflammatory drug (NSAID), is used for pain and inflammation.
Adverse drug reactions require continuous monitoring and reporting.

Observation:

Four cases of severe hepatic injury linked to pirprofen use were reported.
Patients developed liver damage between 3.5 and 6.5 months of daily pirprofen treatment (400-1200 mg).
Histological examination revealed acute hepatocellular damage with bridging necrosis.

Findings:

Two patients died from pirprofen-induced liver injury.
The remaining two patients experienced incomplete recovery.
The reaction appears rare, unpredictable, and not associated with immunoallergic signs, suggesting metabolic idiosyncrasy.

Implications:

Healthcare providers should be aware of the potential for severe hepatotoxicity with pirprofen.
Further investigation into the metabolic pathways of pirprofen is warranted.
This highlights the importance of pharmacovigilance for NSAIDs.

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