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Decreasing Rates of Fracture-Related Hospitalization With Primary Biliary Cholangitis: Insights From the Nationwide

Zaid Ansari1, Ishani Shah2, Abhishek Bhurwal3

  • 1Internal Medicine, Creighton University School of Medicine, Phoenix, USA.

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|June 20, 2022
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Hospitalizations for fractures in primary biliary cholangitis (PBC) patients are decreasing. However, PBC patients with fractures incur higher healthcare costs and longer hospital stays.

Keywords:
bone metabolic diseasefractureshospitalizationosteoporosisprimary biliary cholangitis

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Area of Science:

  • Hepatology
  • Bone Metabolism
  • Healthcare Economics

Background:

  • Primary biliary cholangitis (PBC) is linked to a higher risk of fractures.
  • Current guidelines emphasize fracture prevention in PBC patients.
  • Understanding fracture-related hospitalization trends is crucial for healthcare resource management.

Purpose of the Study:

  • To analyze trends in fracture-related hospitalizations among primary biliary cholangitis patients.
  • To assess the healthcare burden, including length of stay and costs, associated with these hospitalizations.

Main Methods:

  • Retrospective cohort study utilizing the Nationwide Inpatient Sample (NIS) database.
  • Analysis of adult PBC hospitalizations in the US from 2010-2014.
  • Comparison of PBC patients with and without hip, vertebral, or wrist fractures.

Main Results:

  • A statistically significant downward trend in fracture-related hospital admissions for PBC patients was observed (p=0.02).
  • PBC patients with fractures experienced longer hospital stays (10.85 vs 7.36 days; p<0.001).
  • Hospitalization charges were significantly higher for PBC patients with fractures ($98,444 vs $72,964; p=0.004).

Conclusions:

  • Fracture-related hospitalizations in primary biliary cholangitis patients show a declining trend.
  • Despite the decrease, fractures in PBC patients significantly increase healthcare resource utilization and costs.