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Updated: Sep 7, 2025

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

Longitudinal Brain Changes After Stroke and the Association With Cognitive Decline.

Eva B Aamodt^1,2, Stian Lydersen³, Dag Alnæs⁴

¹Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

Frontiers in Neurology

|June 20, 2022

Summary

Brain atrophy is greater in the stroke-affected hemisphere, especially the right hemisphere, after stroke. Greater brain atrophy and larger stroke volumes are linked to cognitive decline over time.

Keywords:

atrophy morphology neurocognitive disorder neuroimaging post-stroke dementia

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Dual-Task Stroop Paradigm for Detecting Cognitive Deficits in High-Functioning Stroke Patients

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Published on: December 16, 2022

Area of Science:

Neuroscience
Neurology
Radiology

Background:

Cognitive impairment and brain atrophy are common after stroke.
Studies indicate greater atrophy in the ipsilesional hemisphere compared to the contralesional hemisphere.
The Nor-COAST study investigates longitudinal associations between stroke, brain atrophy, and cognitive impairment.

Purpose of the Study:

To investigate the longitudinal associations between the lateralization of brain atrophy and the stroke hemisphere.
To examine the relationship between cognitive impairment and brain atrophy over 36 months post-stroke.
To determine if ipsilesional atrophy is greater than contralesional atrophy and its impact on cognition.

Main Methods:

Utilized data from 244 stroke survivors in the prospective Nor-COAST study.
Collected clinical, neuropsychological, and structural MRI data at baseline, 18, and 36 months.
Assessed cognition using the Montreal Cognitive Assessment (MoCA) and brain atrophy via FreeSurfer and ITK-SNAP.

Main Results:

Most cortical and subcortical regions showed higher ipsilesional than contralesional atrophy rates, more pronounced in the right hemisphere.
Greater atrophy in the medial temporal lobe (left-sided strokes) and larger stroke volumes (right-sided strokes) correlated with cognitive decline.
Significant differences in atrophy rates were observed over the 36-month follow-up period.

Conclusions:

Ipsilesional hemisphere atrophy exceeds contralesional atrophy over time, with a more significant effect in the right hemisphere.
This suggests potential higher resilience of the left hemisphere to stroke.
Increased cortical and subcortical atrophy, along with larger stroke volumes, are associated with worse cognitive outcomes and should inform risk assessments.