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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
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Necrosis01:16

Necrosis

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Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
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Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Myasthenia Gravis: Overview and Treatment01:20

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Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
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Translation01:31

Translation

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Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Proteins are...
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Overview of Cell Death01:30

Overview of Cell Death

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Cell death is an essential process where the body gets rid of old or damaged cells. Cell proliferation and death need to be balanced, as an imbalance between the two may lead to cancer or autoimmune diseases.
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the...
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Related Experiment Video

Updated: Sep 7, 2025

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
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Ferroptosis and Autoimmune Diseases.

Benjamin Lai1, Chien-Hsiang Wu2, Chao-Yi Wu3,4

  • 1Department of Internal Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan.

Frontiers in Immunology
|June 20, 2022
PubMed
Summary
This summary is machine-generated.

Ferroptosis, a unique iron-dependent cell death, contributes to autoimmune diseases like lupus and rheumatoid arthritis. Targeting ferroptosis offers a promising therapeutic strategy for these challenging conditions.

Keywords:
ferroptosisinflammationinflammatory bowel diseasesrheumatoid arthritissystemic lupus erythematosus

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Area of Science:

  • Immunology
  • Cell Biology
  • Pathogenesis of Autoimmune Diseases

Background:

  • Autoimmune diseases arise from immune system autoreactivation, posing significant control challenges.
  • Impaired clearance of dead cells releases intracellular components, triggering immune responses and autoimmunity.
  • Ferroptosis, a distinct iron-dependent cell death, differs from apoptosis, necroptosis, autophagy, and pyroptosis.

Purpose of the Study:

  • To review the initiation mechanisms of ferroptosis.
  • To elucidate ferroptosis's contribution to autoimmune disease pathogenesis.
  • To explore targeting ferroptosis as a therapeutic approach for autoimmune diseases.

Main Methods:

  • Review of current literature on ferroptosis and autoimmune diseases.
  • Analysis of molecular mechanisms underlying ferroptosis.
  • Discussion of clinical implications and therapeutic perspectives.

Main Results:

  • Ferroptosis is characterized by its dependence on cellular iron levels.
  • This cell death pathway is implicated in the pathogenesis of systemic lupus erythematosus, rheumatoid arthritis, and inflammatory bowel diseases.
  • Specific mechanisms driving ferroptosis in autoimmunity are detailed.

Conclusions:

  • Ferroptosis plays a significant role in the development of autoimmune diseases.
  • Understanding ferroptosis mechanisms is crucial for developing novel treatments.
  • Targeting ferroptosis presents a potential therapeutic avenue for managing autoimmune conditions.