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The Correlation Between Immune Invasion and SARS-COV-2 Entry Protein ADAM17 in Cancer Patients by Bioinformatic

Kai Wang1, Haoyue Deng1, Binghui Song1

  • 1Key Laboratory of Epigenetics and Oncology, Research Center for Preclinical Medicine, Southwest Medical University, Luzhou, China.

Frontiers in Immunology
|June 20, 2022
PubMed

Insights

ADAM17, a protein regulating SARS-CoV-2 entry, is highly expressed in tumors and linked to poor prognosis. Its correlation with immune cells suggests therapeutic potential for COVID-19 cancer patients.

Area of Science:

  • Oncology
  • Virology
  • Immunology

Background:

  • Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) caused the COVID-19 pandemic.
  • ADAM17 (a disintegrin and transmembrane metalloproteinase domain protein) regulates the SARS-CoV-2 receptor ACE2.
  • The role of ADAM17 in COVID-19 infected cancer patients and its immune cell infiltration correlation remain unclear.

Purpose of the Study:

  • To investigate ADAM17 expression in normal versus tumor tissues.
  • To analyze the correlation between ADAM17 expression, immune cell infiltration, and immunomodulators.
  • To identify potential drugs targeting ADAM17.

Main Methods:

  • Gene Expression Profiling Interactive Analysis (GEPIA) for tissue expression comparison.
  • Correlation analysis for ADAM17 with immune infiltration and immunomodulators.
  • Therapeutic drug screening using the TISDB database.

Main Results:

  • ADAM17 is highly conserved and expressed in lung, brain, lymphoid tissues, and respiratory cells.
  • Tumor ADAM17 expression is elevated compared to normal tissues, correlating with negative patient prognosis.
  • ADAM17 expression significantly correlates with immunomodulators and immune cell infiltration in both normal and tumor tissues.
  • Eight small molecules targeting ADAM17 showed therapeutic significance.

Conclusions:

  • ADAM17 has significant implications for cancer patients with COVID-19.
  • ADAM17's role in immune modulation and infiltration offers new therapeutic strategies for COVID-19.
  • Targeting ADAM17 may provide a novel approach for treating COVID-19 in cancer patients.
Keywords:
ADAM17SARS-CoV-2cancersmall moleculesusceptibilitytherapeutics

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