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Related Concept Videos

Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

31
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
31
Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

24
During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
24
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

32
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
32

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Related Experiment Video

Updated: Sep 7, 2025

Compensatory Limb Use and Behavioral Assessment of Motor Skill Learning Following Sensorimotor Cortex Injury in a Mouse Model of Ischemic Stroke
08:01

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Peripheral Organ Injury After Stroke.

Jin Wang1,2, Jiehua Zhang3, Yingze Ye1,2

  • 1Central Laboratory, Renmin Hospital of Wuhan University, Wuhan, China.

Frontiers in Immunology
|June 20, 2022
PubMed
Summary
This summary is machine-generated.

Stroke causes high mortality and disability, often leading to peripheral organ damage due to inflammation and immunosuppression. Early detection and treatment of these nonneurological complications are crucial for better patient outcomes.

Keywords:
gastrointestinal tractheartkidneylungperipheral organ injuryspleenstroke

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Area of Science:

  • Neurology
  • Pathophysiology
  • Internal Medicine

Background:

  • Stroke is a leading cause of adult disability with high mortality rates.
  • Cerebral arterial embolism or bleeding causes stroke, with limited effective treatments beyond recombinant tissue plasminogen activator (rt-PA).
  • Stroke frequently induces damage to peripheral organs like lungs, heart, and kidneys.

Purpose of the Study:

  • To review the pathophysiological mechanisms of peripheral organ injury following stroke.
  • To outline the clinical manifestations of stroke-induced organ damage.
  • To discuss current and potential treatments for these nonneurological complications.

Main Methods:

  • Literature review of pathophysiological mechanisms.
  • Analysis of clinical manifestations and diagnostic approaches.
  • Synthesis of treatment strategies for peripheral organ injury.

Main Results:

  • Acute stroke involves brain inflammation and peripheral immunosuppression, increasing infection risk and organ damage.
  • Nonneurological complications significantly impact stroke prognosis, leading to prolonged hospitalization and increased mortality.
  • Many stroke-related peripheral organ complications are preventable and treatable.

Conclusions:

  • Peripheral organ injury is a significant and often overlooked consequence of stroke.
  • Understanding the pathophysiology is key to managing and preventing these complications.
  • Integrated medical strategies are essential for mitigating the adverse effects of stroke on non-neurological organs.