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A prospective study on hyperhomocysteinemia as an aggravating factor in chronic venous insufficiency

Maria Rotaru1,2, Gabriela Mariana Iancu1,2, Ioana Baldovin2,3

  • 1Department of Dermatology, Faculty of Medicine, 'Lucian Blaga' University of Sibiu, 550169 Sibiu, Romania.

Experimental and Therapeutic Medicine
|June 20, 2022
PubMed

Insights

Hyperhomocysteinemia (HH) is a significant factor in chronic venous insufficiency (CVI), increasing thrombotic risk. This condition, often moderate, is linked to venous ulcers and other serious complications, particularly in older patients.

Area of Science:

  • Vascular Medicine
  • Biochemistry
  • Thrombosis Research

Background:

  • Hyperhomocysteinemia (HH) is a known risk factor for systemic thrombotic events.
  • Its role in chronic venous insufficiency (CVI) remains understudied.
  • CVI affects a significant portion of the population, leading to substantial morbidity.

Purpose of the Study:

  • To investigate the prevalence and impact of HH in patients with CVI (stages C3-C6).
  • To analyze the relationship between HH, inflammatory markers, metabolic profiles, and procoagulant factors in CVI patients.
  • To assess the influence of age and disease duration on homocysteine levels in CVI.

Main Methods:

  • Prospective study of 166 CVI patients.
  • High-performance liquid chromatography (HPLC) for homocysteine level determination.
  • Assessment of inflammatory, metabolic, and procoagulant profiles, including smoking and abortion history.

Main Results:

  • HH was present in 54.22% of CVI patients, predominantly moderate.
  • Common procoagulant factors included smoking (21.67%) and abortions in women (31.93%).
  • Altered metabolic profiles (42.77%) and proinflammatory status (23.50%) were observed.
  • Elevated homocysteine levels correlated with age (>75 years) and disease duration (>20 years).
  • HH was associated with venous ulcers, thrombophlebitis, and pulmonary thromboembolisms.

Conclusions:

  • HH is a significant contributing factor to CVI pathogenesis, alongside chronic inflammation.
  • HH exacerbates thrombogenic risk in CVI patients.
  • Elderly patients and those with long-standing venous disease are at higher risk.

Keywords:
aggravating factorchronic venous insufficiencyhyperhomocysteinemiaprocoagulant statethrombosis

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