Changes in personality traits in patients with Alzheimer's Disease

Changes in personality traits in patients with Alzheimer's disease (AD) are extremely common throughout the course of the pathology, and these behavioral changes present themselves as challenges in clinical management and as a significant cause of caregivers' burden.

Using a personality inventory based on the five-factor model of personality, this study aimed to assesses the change in these factors by comparing the premorbid and current personality of individuals recently diagnosed with AD.

A total of 30 AD patients were recruited, and their respective family members responded to the personality inventory at home through a hosted site. The patients were also divided into two groups according to the Clinical Dementia Rating (CDR): mild dementia (CDR 1) and moderate dementia (CDR 2).

Among all patients, there was a significant increase in neuroticism factor levels and a significant decrease in the extraversion, conscientiousness, openness, and socialization factors. When comparing the groups, only the extraversion factor showed a difference, with CDR 1 group accusing a higher change in scores. Higher scores in the factor neuroticism in the premorbid personality correlated with the current severity of the disease.

This research draws the attention of family members and health professionals to changes in personality traits or behavior of relatives or patients, because it can reflect an underlying neurodegenerative process.