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Updated: Sep 7, 2025
07:28
Donor Posterior Atrial Flap Rotation for Left Atrial Cuff Reconstruction in Lung Transplantation
Published on: October 11, 2024
422
Changes in Thoracic Cavity Volume After Bilateral Lung Transplantation
Woo Sik Yu1, Chul Hwan Park2, Hyo Chae Paik3
1Department of Thoracic and Cardiovascular Surgery, Ajou University School of Medicine, Suwon, South Korea.
Frontiers in Medicine
|June 20, 2022
Summary
Lung transplantation reverses chest cavity changes caused by lung disease. Restrictive lung diseases increase thoracic cavity volume post-transplant, while obstructive diseases decrease it.
Area of Science:
- Pulmonary Medicine
- Thoracic Surgery
- Radiology
Background:
- End-stage lung diseases cause significant anatomical changes in the thoracic cavity.
- Limited research exists on thoracic cavity volume (TCV) changes following lung transplantation (LTx).
Purpose of the Study:
- To investigate the relationship between changes in thoracic cavity volume (TCV) after lung transplantation (LTx) and the patient's underlying lung disease.
- To assess the reversibility of disease-specific chest remodeling post-LTx.
Main Methods:
- Retrospective review of 89 patients undergoing LTx.
- Comparison of pre-LTx and 1-year post-LTx chest computed tomography (CT) scans to measure TCV.
- Classification of patients into obstructive or restrictive groups based on pre-LTx pulmonary function tests (PFTs).
Main Results:
- TCV significantly increased in the restrictive group post-LTx (2,347.8 to 3,224.4 mL, p < 0.001).
- TCV significantly decreased in the obstructive group post-LTx (4,662.9 to 3,711.1 mL, p < 0.001).
- Restrictive lung disease, taller stature, lower BMI, and larger donor lungs were independently associated with increased TCV post-LTx.
Conclusions:
- Chest remodeling due to restrictive lung disease and hyperinflation is partially reversible after LTx.
- Post-LTx chest remodeling appears to counteract the remodeling caused by the original lung disease.
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