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A Cohort Study to Compare Effects between Ulcer- and Nonulcer-Related Nonvariceal Upper Gastrointestinal Bleeding
Bi Nian1, Bangping Wang1, Long Wang2
1Department of Gastroenterology, Suzhou First People's Hospital, China.
Insights
Peptic ulcers are the leading cause of acute nonvariceal upper gastrointestinal bleeding (ANVUGIB). NSAID use is a major trigger in the elderly, while lifestyle factors affect younger patients more.
Area of Science:
- Gastroenterology
- Internal Medicine
- Clinical Research
Background:
- Acute nonvariceal upper gastrointestinal bleeding (ANVUGIB) is a significant clinical concern.
- Understanding regional characteristics and etiology is crucial for evidence-based management.
Purpose of the Study:
- To investigate the epidemiological characteristics and etiological factors of ANVUGIB.
- To analyze age-related differences in ANVUGIB causes and triggers.
- To provide updated medical evidence for clinical practice.
Main Methods:
- Retrospective analysis of 100 ANVUGIB patients admitted between January 2017 and December 2021.
- Patients categorized into young (18-39), middle-aged (40-59), and elderly (60+).
- Etiology confirmed via endoscopy; data analyzed using SPSS 23.0.
Main Results:
- Peptic ulcers were the primary cause of ANVUGIB.
- Gastric ulcers predominated in the elderly, while duodenal ulcers were more common in younger groups.
- NSAID use was a significant trigger in the elderly, unlike younger demographics where lifestyle factors were more prevalent.
Conclusions:
- Peptic ulcer disease remains the most frequent cause of ANVUGIB.
- Acute gastric mucosal lesions and upper digestive system tumors are less common causes compared to ulcers.
- Age-specific etiological factors and triggers necessitate tailored clinical approaches.
Objective:
The aim of this study was to better understand the characteristics and etiology of acute nonvariceal upper gastrointestinal bleeding (ANVUGIB) in recent years in this region and to provide evidence-based medical evidence.
Methods:
100 patients with acute nonvariceal upper gastrointestinal bleeding (ANVUGIB) who met the clinical diagnostic criteria of ANVUGIB admitted to Suzhou First People's Hospital from January 2017 to December 2021 were analyzed, as well as the age difference and change rule. According to age, 100 patients were divided into young (18-39 years), middle-aged (40-59 years), and elderly (60 years and above), and the differences in the three groups were compared. The etiology was confirmed by endoscopic examination and was recorded one by one in a well-designed ANVUGIB case data registration form. Statistical software SPSS 23.0 was used for analysis.
Results:
Gastric ulcer was the main cause in the elderly group (50.0%), duodenal ulcer was the main cause in the middle and young groups, and gastrointestinal cancer (7.1%) and marginal ulcer (2.3%) in the elderly group were higher than those in the young group. Nonsteroidal anti-inflammatory drugs (52.3%) were the main inducement in the elderly group, which was significantly higher than in the middle-aged group (13.1%) and the young group (5%) (P < 0.01). Drinking, fatigue, and emotional excitement led to a higher proportion in the middle-aged group and the young group, in comparison to the elderly group (P < 0.01).
Conclusion:
Peptic ulcer is the most common cause of acute nonvariceal upper gastrointestinal bleeding, followed by acute gastric mucosal lesions and upper digestive system tumors, compared with nonulcer.
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