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Comparative characterisation of COVID-19 patients with hypertension comorbidity in Malawi: a 1:2 matched

Master R O Chisale1, Billy W Nyambalo2, Collins Mitambo2

  • 1Biological Sciences Department, Mzuzu University, Mzuzu, Malawi.

IJID Regions
|June 20, 2022
PubMed

Insights

Hypertensive patients with COVID-19 in Malawi faced higher mortality risks, especially with increasing age and comorbidities like HIV and TB. Identifying these risk factors is crucial for better clinical outcomes.

Area of Science:

  • Epidemiology
  • Infectious Diseases
  • Public Health

Background:

  • Hypertension is a significant global health concern.
  • COVID-19 has disproportionately affected individuals with pre-existing conditions.
  • Understanding mortality risk factors in hypertensive COVID-19 patients is critical for targeted interventions.

Purpose of the Study:

  • To characterize COVID-19 cases in Malawi.
  • To explore risk factors for mortality among hypertensive patients with COVID-19.

Main Methods:

  • Retrospective case-control study design.
  • Inclusion of 441 patients (1:2 case-to-control ratio), matched by age.
  • Analysis of clinical data and comorbidities.

Main Results:

  • Higher COVID-19 mortality rates were observed in hypertensive patients.
  • Hypertensive patients exhibited more severe symptoms compared to non-hypertensive individuals.
  • Mortality risk increased with age and was associated with comorbidities (HIV, TB, cardiovascular, liver disease).

Conclusions:

  • Identified predictive factors for mortality in hypertensive COVID-19 patients.
  • Findings can inform healthcare policy and clinical practice for high-risk individuals.
  • Recommendations for tailored treatment approaches to improve patient outcomes.
Abstract

Keywords:
COVID-19case-control studyhypertensionmortalityrisk factor

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